When someone stops taking hormone replacement therapy (HRT) suddenly, it can cause several effects in the body. Some potential effects include: Withdrawal effects - Many people report withdrawal effects when stopping HRT suddenly, especially if they have taken it for a long period of time. The body gets used to supplemental hormones from HRT, so abruptly stopping can cause a shock to the system. Menopause-like symptoms returning - Symptoms of menopause that were controlled by HRT may come back suddenly. These include hot flashes, night sweats, vaginal dryness, mood changes, trouble sleeping, and more. The severity depends on the individual. Bone loss risk increasing - Estrogen from HRT helps maintain healthy bone density. Without it, the risk of developing osteoporosis and bone fractures can increase significantly over time. Regular monitoring of bone health is important. Heart health issues - HRT with estrogen may provide protective benefits for heart health. Abruptly stopping could increase the risks of cardiovascular disease over time in some women. Other withdrawal effects - Headaches, joint pain, fatigue, nausea, and weight fluctuations are possible for some when stopping HRT use suddenly. The duration and intensity varies individually. Emotional changes - Some report depression, anxiety, irritability and trouble concentrating when first quitting HRT. Emotional volatility is common when hormones are in flux. It depends on duration of prior use - The body adjusts to consistent hormone levels provided by HRT. If used short-term, stopping effects may be minimal. But for long-term use the body has adjusted, so stopping can be a bigger shock. Effects can take time to develop - Some effects emerge right after quitting, but others may take weeks or months to fully manifest. Timelines vary individually. Effects may stabilize over time - The body does try to re-regulate hormone production and find balance again. Many symptoms improve and stabilize, but changes in bone health and heart disease risk factors may be prolonged. Safest to taper down slowly - Because sudden HRT cessation can cause notable effects, most doctors recommend a gradual taper down in dose over weeks or months. This gives the body more time to readjust internal hormone production.